Normalization of the tumor vasculature through oncogenic inhibition: An emerging paradigm in tumor biology
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چکیده
منابع مشابه
Normalization of the tumor vasculature through oncogenic inhibition: an emerging paradigm in tumor biology.
The work by Bottos et al. (1) reported the effects of the protooncogene BRAF inhibition on the vasculature of solid tumors harboring the BRAF oncogenic mutation. In particular, the work by Bottos et al. (1) showed that suppression of BRAF signaling in these tumors diminished tumor cell expression of several proangiogenic factors downstream of BRAF, which in turn stabilized vessel architecture, ...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2012
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1203794109